From JanimeS: I.S. (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality. I.S. stands for Inter Sexuality. This manga deals with very serious issues with intersexuality people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are - It's all there in a form of manga. The series is consisted with cases, each deals with different people though some cases are much longer and more dramatic than others.